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Alprazolam(Xanax, Xanax XR, Helix, Tafil, Niravam, Aceprax, Alplax, Alpralid, Alprax, Alviz, Alzolam, Apo-Alpraz, Apraz, Calmax, Constan, Frontal XR, Frontal, Frontin, Helex, Kalma, Kinax, Ksalol, Manorest, Neurol, Prazolex, Ralozam, Restyl, Sedipral, Solanax, Tafil AP, Trankimazin, Tranquinal, Xanor, Zamhexal, Zolarem, Zoldac)
Alprazolam Use
Benzodiazepine anxiolytic. Anxiety disorders: Adults, initially, 0.25 mg Alprazolam 2 or 3 times daily. Increase dosage by 0.25 mg Alprazolam increments, if required. Maximum: 3 mg/day in divided doses.
Elderly or debilitated patients: Initially, 0.125 mg Alprazolam 2 or 3 times daily; increased gradually, if required, depending on tolerance and response.
Impaired hepatic or renal function: 0.125-0.25 mg Alprazolam 2 or 3times daily. Increase gradually if needed and tolerated.
Panic disorders: Initially, 0.5 - 1 mg Alprazolam at bedtime or 0.5 mg 3 times/day. Increase by increments no greater than 1 mg every 3-4 days until patient is free of attacks.
Some patients may require up to 10 mg/day. Discontinue Alprazolam slowly by decreasing the daily dosage by no more than 0.5 mg every 3 days. A decrease of 0.5 mg every 2-3 weeks is more appropriate when Alprazolam dose of 6 mg daily or more has been administered even for only a few months. Once a dose of 2 mg daily is achieved, decrease the dose by 0.25 mg per 2 to 3 weeks.
Alprazolam Contraindications
Myasthenia gravis, acute narrow angle glaucoma.
Alprazolam Precautions
Alprazolam is not recommended in pregnant women, nursing mothers, patients < 18 years of age, psychotic or depressed patients, individuals prone to drug or alcohol abuse. Use with caution in elderly or debilitated patients and those with impaired renal or hepatic function. Avoid abrupt withdrawal of Alprazolam. For repeated cycles of therapy, perform periodic blood counts and hepatic function tests.
Alprazolam Side effects
Drowsiness, dizziness, coordination difficulties. Release of hostility and other paradoxical effects such as irritability and hallucinations may occur with benzodiazepines.
Alprazolam Interactions
Co-administration with antifungal agents such as ketoconazole or itraconazole is not recommended. Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction). Fluoxetine, OCs, sertraline, diltiazem, macrolide antibiotics (exercise caution).
Alprazolam Patient tips
Warn against concomitant use of alcohol and other CNS depressants. Caution re dizziness, drowsiness (NB driving).
Alprazolam Supplied
0.25 mg, 0.5 mg 1 mg, 2 mg Alprazolam tablets.
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